4.3 Review

Naringenin: A Promising Therapeutic Agent against Organ Fibrosis

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

New Perspectives in the Pharmacological Potential of Naringin in Medicine

Maria Angelica Rivoira et al.

Summary: NAR has shown positive effects on cardiovascular diseases, metabolic syndrome, and cancer. Current formulations of NAR seem to enhance its bioavailability, but there is still limited research, necessitating further investigation.

CURRENT MEDICINAL CHEMISTRY (2021)

Review Dermatology

The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets

Julie K. Nguyen et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2020)

Review Medicine, Research & Experimental

Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation

Stuart A. Cook et al.

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

Article Pharmacology & Pharmacy

Albumin self-modified liposomes for hepatic fibrosis therapy via SPARC-dependent pathways

Jianzhu Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Cell Biology

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

Kenneth W. Finnson et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

Review Pharmacology & Pharmacy

Naringenin and naringin in cardiovascular disease prevention: A preclinical review

Reza Heidary Moghaddam et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Cellular and molecular mechanisms of kidney fibrosis

Sonja Djudjaj et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

Review Biochemistry & Molecular Biology

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

Ralf Weiskirchen et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

The Smad3-miR-29b/miR-29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis

Jing-nan Liang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Rheumatology

Shared and distinct mechanisms of fibrosis

Joerg H. W. Distler et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

Article Multidisciplinary Sciences

The citrus flavonoid naringenin impairs the in vitro infection of human cells by Zika virus

Allan Henrique Depieri Cataneo et al.

SCIENTIFIC REPORTS (2019)

Article Pharmacology & Pharmacy

Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways

Erika Hernandez-Aquino et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Medicine, General & Internal

Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats

Zhizhi Wang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

New insights into TGF-β/Smad signaling in tissue fibrosis

He-He Hu et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2018)

Article Cell Biology

Involvement of Smad3 pathway in atrial fibrosis induced by elevated hydrostatic pressure

Wei Wei et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Pharmacology & Pharmacy

Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1β Level

Chao Zhang et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)

Review Medicine, Research & Experimental

Combating oxidative stress disorders with citrus flavonoid: Naringenin

Nurul Hannim Zaidun et al.

LIFE SCIENCES (2018)

Review Pharmacology & Pharmacy

Naringenin as a potential immunomodulator in therapeutics

Wenfeng Zeng et al.

PHARMACOLOGICAL RESEARCH (2018)

Review Pharmacology & Pharmacy

Natural Products as a Source for Antifibrosis Therapy

Dan-Qian Chen et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Review Medicine, Research & Experimental

Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

Ruthvika Joshi et al.

LIFE SCIENCES (2018)

Article Pharmacology & Pharmacy

Toll-like receptors in the pathogenesis of pulmonary fibrosis

Theodoros Karampitsakos et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Review Genetics & Heredity

PDGFs and their receptors

Andrius Kazlauskas

Review Cell Biology

Signalling pathways involved in hypoxia-induced renal fibrosis

Minna Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Review Medicine, General & Internal

Chronic kidney disease

Angela C. Webster et al.

LANCET (2017)

Review Transplantation

The ascending rank of chronic kidney disease in the global burden of disease study

Kitty J. Jager et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

Article Gastroenterology & Hepatology

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways

Erika Hernandez-Aquino et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Article Urology & Nephrology

Treatment of Renal Fibrosis-Turning Challenges into Opportunities

Barbara M. Klinkhammer et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2017)

Review Cell Biology

Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration

Virpi Talman et al.

CELL AND TISSUE RESEARCH (2016)

Article Medicine, Research & Experimental

Versican: a novel modulator of hepatic fibrosis

Terence N. Bukong et al.

LABORATORY INVESTIGATION (2016)

Review Urology & Nephrology

TGF-β: the master regulator of fibrosis

Xiao-ming Meng et al.

NATURE REVIEWS NEPHROLOGY (2016)

Article Endocrinology & Metabolism

Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy

Ning Yan et al.

JOURNAL OF DIABETES RESEARCH (2016)

Review Medicine, General & Internal

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

Sonsoles Piera-Velazquez et al.

JOURNAL OF CLINICAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

Naringenin and Atherosclerosis: A Review of Literature

Ilkay E. Orhan et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2015)

Article Pharmacology & Pharmacy

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Saeed Ghofrani et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

Article Immunology

Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation

Vengadeshprabhu Karuppagounder et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2015)

Review Medicine, General & Internal

Fibrosis - A Common Pathway to Organ Injury and Failure

Don C. Rockey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, Research & Experimental

Naringenin attenuates pressure overload-induced cardiac hypertrophy

Ning Zhang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

Review Gastroenterology & Hepatology

Reversibility of liver fibrosis

Mengxi Sun et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2015)

Review Cell Biology

Modulation of angiotensin II signaling in the prevention of fibrosis

Amanda M. Murphy et al.

FIBROGENESIS & TISSUE REPAIR (2015)

Review Biochemistry & Molecular Biology

Myofibroblast Differentiation: Main Features, Biomedical Relevance, and the Role of Reactive Oxygen Species

Alessandro Siani et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Pharmacology & Pharmacy

Naringenin attenuates CCl4-induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats

Mohammad Ali Esmaeili et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2014)

Review Biochemistry & Molecular Biology

Potential Roles of BMP9 in Liver Fibrosis

Jianjun Bi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Oncology

Naringenin inhibits allergen-induced airway remodeling in a murine model of asthma

Ying Shi et al.

MOLECULAR MEDICINE REPORTS (2014)

Article Medicine, General & Internal

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Talmadge E. King et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Luca Richeldi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Letter Oncology

Tumor Growth Attenuating Effects of Naringenin

Shailendra Kapoor

PATHOLOGY & ONCOLOGY RESEARCH (2014)

Article Gastroenterology & Hepatology

Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

Gulsum Ozlem Elpek

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Urology & Nephrology

EGFR signaling in renal fibrosis

Shougang Zhuang et al.

KIDNEY INTERNATIONAL SUPPLEMENTS (2014)

Review Biochemistry & Molecular Biology

Strategies for anti-fibrotic therapies

Joel Rosenbloom et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Review Respiratory System

The pathogenesis of pulmonary fibrosis: a moving target

Wim A. Wuyts et al.

EUROPEAN RESPIRATORY JOURNAL (2013)

Review Medicine, Research & Experimental

Molecular basis of organ fibrosis: Potential therapeutic approaches

Asish K. Ghosh et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

Article Environmental Sciences

Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains

Sun Hee Moon et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2013)

Article Rheumatology

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

Angelika Horn et al.

ARTHRITIS AND RHEUMATISM (2012)

Article Biochemistry & Molecular Biology

Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin-nicotinamide-induced experimental diabetic rats

T. Annadurai et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Thomas A. Wynn et al.

NATURE MEDICINE (2012)

Review Biotechnology & Applied Microbiology

Targeting the TGFβ signalling pathway in disease

Rosemary J. Akhurst et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Toxicology

Anti-inflammatory role of naringenin in rats with ethanol induced liver injury

Jayachitra Jayaraman et al.

TOXICOLOGY MECHANISMS AND METHODS (2012)

Review Biotechnology & Applied Microbiology

Naringinases: occurrence, characteristics, and applications

Maria H. Ribeiro

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

Editorial Material Biochemistry & Molecular Biology

Scraping fibrosis

Wajahat Z. Mehal et al.

NATURE MEDICINE (2011)

Article Cell Biology

Recommendations on clinical proof of efficacy for potential scar prevention and reduction therapies

James A. Bush et al.

WOUND REPAIR AND REGENERATION (2011)

Article Pathology

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

Benjamin D. Humphreys et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Medicine, Research & Experimental

Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats

Tety Leonardi et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2010)

Review Biochemistry & Molecular Biology

Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis

Corrine R. Kliment et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Pharmacology & Pharmacy

Potential beneficial effect of naringenin on lipid peroxidation and antioxidant status in rats with ethanol-induced hepatotoxicity

Jayachitra Jayaraman et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2010)

Article Agriculture, Multidisciplinary

Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study

Monica Cavia-Saiz et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2010)

Review Gastroenterology & Hepatology

Evolving challenges in hepatic fibrosis

Scott L. Friedman

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)

Article Medicine, Research & Experimental

Pathophysiological Consequences of HIF Activation HIF as a Modulator of Fibrosis

Volker H. Haase

HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY (2009)

Review Cell Biology

Non-Smad pathways in TGF-beta signaling

Ying E. Zhang

CELL RESEARCH (2009)

Article Gastroenterology & Hepatology

The Global Impact of Hepatic Fibrosis and End-Stage Liver Disease

Young-Suk Lim et al.

CLINICS IN LIVER DISEASE (2008)

Review Biochemistry & Molecular Biology

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

Xu Shi-Wen et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2008)

Review Oncology

Cellular and molecular mechanisms of fibrosis

T. A. Wynn

JOURNAL OF PATHOLOGY (2008)

Article Surgery

The hidden cost of skin scars: quality of life after skin scarring

B. C. Brown et al.

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY (2008)

Review Cardiac & Cardiovascular Systems

Atrial fibrosis: Mechanisms and clinical relevance in atrial fibrillation

Brett Burstein et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)

Review Biochemistry & Molecular Biology

Flavonoid composition of citrus juices

Giuseppe Gattuso et al.

MOLECULES (2007)

Article Pathology

The myofibroblast - One function, multiple origins

Boris Hinz et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

Article Medical Laboratory Technology

Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats

Seon-Min Jeon et al.

TRANSLATIONAL RESEARCH (2007)

Article Biochemistry & Molecular Biology

Fibroblasts and myofibroblasts: Their source, function and role in disease

Robin J. McAnulty

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Dermatology

Quality of life of patients with keloid and hypertrophic scarring

O Bock et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2006)

Article Pharmacology & Pharmacy

Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice

S Kanno et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)

Review Biochemistry & Molecular Biology

Regulation of PDGF and its receptors in fibrotic diseases

JC Bonner

CYTOKINE & GROWTH FACTOR REVIEWS (2004)

Article Pharmacology & Pharmacy

The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats

MH Lee et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2004)

Review Rheumatology

Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis

AE Postlethwaite et al.

CURRENT OPINION IN RHEUMATOLOGY (2004)

Review Medicine, General & Internal

Skin scarring

A Bayat et al.

BRITISH MEDICAL JOURNAL (2003)

Article Medicine, Research & Experimental

Comparison of metabolic pharmacokinetics of naringin and naringenin in rabbits

SL Hsiu et al.

LIFE SCIENCES (2002)

Article Gastroenterology & Hepatology

Bioavailability of the flavanone naringenin and its glycosides in rats

C Felgines et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)