4.3 Article

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-κB Suppression and NLRP3 Inflammasome Inhibition

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage

Pengfei Xu et al.

Summary: The study showed that inhibiting TREM-1 can improve brain injury caused by SAH, while activation of TREM-1 exacerbates these damages, indicating the critical role of TREM-1 in neuroinflammation.

TRANSLATIONAL STROKE RESEARCH (2021)

Article Immunology

The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

Maximilian Franke et al.

Summary: The study demonstrates that induction of NLRP3 inflammasome in neurons plays a crucial role in neuroinflammation during acute ischemic stroke. Early blockade of NLRP3 can protect against I/R injury by reducing inflammation and stabilizing the blood-brain barrier.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Neurosciences

Mutant erythropoietin enhances white matter repair via the JAK2/STAT3 and C/EBPβ pathway in middle-aged mice following cerebral ischemia and reperfusion

Rongliang Wang et al.

Summary: This study demonstrates that nonerythropoietic mutant EPO (MEPO) has neuroprotective effects on white matter injury in middle-aged male mice following cerebral ischemia by promoting microglial M2 polarization and oligodendrogenesis. This effect is achieved through the activation of JAK2/STAT3 and inhibition of the C/EBP beta signaling pathway.

EXPERIMENTAL NEUROLOGY (2021)

Article Neurosciences

Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination

Jiayin Zheng et al.

Summary: The study revealed that Activin A improves neurological outcomes in mice with ischemic stroke by promoting oligodendroglial ACVR1B-mediated white matter remyelination, suggesting a potential therapeutic strategy.

EXPERIMENTAL NEUROLOGY (2021)

Article Immunology

Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis

Chronic cerebral Hypoperfusion et al.

Summary: Findings suggest that curcumin shows promising therapeutic effects on cognitive impairments induced by diabetes and chronic cerebral hypoperfusion, potentially through suppressing neuroinflammation and reducing cell apoptosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Neuroprotective Effects of Curcumin in Cerebral Ischemia: Cellular and Molecular Mechanisms

Lalita Subedi et al.

Summary: Curcumin, a polyphenol abundant in turmeric, has shown promising neuroprotective effects in animal models of neurodegenerative diseases, including cerebral ischemia. Its pleiotropic effects in the postischemic brain, such as antioxidant and anti-inflammatory properties, make it a potential therapeutic strategy for treating cerebral ischemia. Studies have validated its neuroprotective effects in both ischemic and hemorrhagic stroke, demonstrating its broad-spectrum efficacy in protecting the brain.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Critical Care Medicine

Curcumin Protects against White Matter Injury through NF-κB and Nrf2 Cross Talk

Amita Daverey et al.

JOURNAL OF NEUROTRAUMA (2020)

Article Biochemistry & Molecular Biology

Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury

Maryna Baydyuk et al.

NEUROCHEMICAL RESEARCH (2020)

Review Neurosciences

Translating concepts of neural repair after stroke: Structural and functional targets for recovery

Robert W. Regenhardt et al.

RESTORATIVE NEUROLOGY AND NEUROSCIENCE (2020)

Review Pharmacology & Pharmacy

Curcumin: an inflammasome silencer

Shima Hasanzadeh et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Cardiac & Cardiovascular Systems

Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner

Wei Yu et al.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2020)

Review Neurosciences

Mechanisms of demyelination and remyelination in the young and aged brain following white matter stroke

Miguel Alejandro Marin et al.

NEUROBIOLOGY OF DISEASE (2019)

Article Immunology

LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke

Xi Zhang et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Article Clinical Neurology

Global brain inflammation in stroke

Kaibin Shi et al.

LANCET NEUROLOGY (2019)

Article Physiology

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury

Eridan Rocha-Ferreira et al.

FRONTIERS IN PHYSIOLOGY (2019)

Article Neurosciences

Long-term effects of curcumin in the non-human primate brain

Bang-Bon Koo et al.

BRAIN RESEARCH BULLETIN (2018)

Article Multidisciplinary Sciences

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

Brienne A. McKenzie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

Saifudeen Ismael et al.

SCIENTIFIC REPORTS (2018)

Article Neurosciences

The biphasic function of microglia in ischemic stroke

Yuanyuan Ma et al.

PROGRESS IN NEUROBIOLOGY (2017)

Article Medicine, Research & Experimental

Curcumin inhibits endoplasmic reticulum stress induced by cerebral ischemia-reperfusion injury in rats

Haiying Zhu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

Article Geriatrics & Gerontology

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

Zongjian Liu et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Article Clinical Neurology

Curcumin protects against stroke and increases levels of Notch intracellular domain

Shuang Liu et al.

NEUROLOGICAL RESEARCH (2016)

Article Neurosciences

White matter injury in ischemic stroke

Yuan Wang et al.

PROGRESS IN NEUROBIOLOGY (2016)

Letter Biology

Gasdermins pore cell membrane to pyroptosis

Huanhuan Liang et al.

SCIENCE CHINA-LIFE SCIENCES (2016)

Article Clinical Neurology

Microglial and macrophage polarization -new prospects for brain repair

Xiaoming Hu et al.

NATURE REVIEWS NEUROLOGY (2015)

Article Clinical Neurology

Protecting White Matter From Stroke Injury

Carlos Matute et al.

STROKE (2013)

Article Clinical Neurology

Evolution of Inflammation and White Matter Injury in a Model of Transient Focal Ischemia

Iska Moxon-Emre et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)

Article Multidisciplinary Sciences

Erythropoietin Amplifies Stroke-Induced Oligodendrogenesis in the Rat

Li Zhang et al.

PLOS ONE (2010)

Review Pharmacology & Pharmacy

Oligovascular Signaling in White Matter Stroke

Ken Arai et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)

Review Medicine, Research & Experimental

Bioavailability of curcumin: Problems and promises

Preetha Anand et al.

MOLECULAR PHARMACEUTICS (2007)