Journal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/7292512
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [81902243]
- Zhejiang Provincial Natural Science Foundation of China [LQ19H060004]
- Wenzhou Science and Technology Bureau Foundation [ZY2019014]
- Lin He's New Medicine and Clinical Translation Academician Workstation Research Fund [18331213]
Ask authors/readers for more resources
The study found that limonin can alleviate symptoms of arthritis by activating the Nrf2/HO1/NF-kappa B pathway.
Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has been reported to have anti-inflammatory effects, while inflammation is a major cause of OA; thus, we propose that limonin may have a therapeutic effect on OA. In this study, the therapeutic effect of limonin on OA was assessed in chondrocytes in vitro in IL-1 beta induced OA and in the destabilization of the medial meniscus (DMM) mice in vivo. The Nrf2/HO-1/NF-kappa B signaling pathway was evaluated to illustrate the working mechanism of limonin on OA in chondrocytes. In this study, it was found that limonin can reduce the level of IL-1 beta induced proinflammatory cytokines such as INOS, COX-2, PGE2, NO, TNF-alpha, and IL-6. Limonin can also diminish the biosynthesis of IL-1 beta-stimulated chondrogenic catabolic enzymes such as MMP13 and ADAMTS5 in chondrocytes. The research on the mechanism study demonstrated that limonin exerts its protective effect on OA through the Nrf2/HO-1/NF-kappa B signaling pathway. Taken together, the present study shows that limonin may activate the Nrf2/HO1/NF-kappa B pathway to alleviate OA, making it a candidate therapeutic agent for OA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available