Tetrahydro-4H-pyran-4-one: From the Laboratory Scale to Pilot Plant Manufacture

This study describes our recent efforts to find an efficient and scalable route to tetrahydro-4H-pyran-4-one using the commercially available starting materials. The route scouting work and the full development of an efficient access to the target are described. This work culminated in the preparation of above 20 kg of the title compound in our pilot plant facility.

Automated summary

This study describes the recent efforts to find an efficient and scalable route to tetrahydro-4H-pyran-4-one using commercially available starting materials. The work culminated in the preparation of over 20 kg of the title compound in the pilot plant facility.