Journal
ORGANIC LETTERS
Volume 23, Issue 20, Pages 7824-7828Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02842
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Funding
- NSFC [22031004, 21921003, 21901043]
- Shanghai Municipal Education Commission [20212308]
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Polycyclic polyprenylated acylphloroglucinols (PPAPs) with a common bicyclo[3.3.1]alkenone core structure have attracted attention for their biological properties and synthetic challenges. Pd-phosphoramidite catalysts were found to promote the enantioselective dearomative allylic annulation reaction, likely proceeding through a two-step dearomative allylation by Pd with the C-allylation pathway being dominant.
Polycyclic polyprenylated acylphloroglucinols (PPAPs) share a common bicyclo[3.3.1]alkenone core structure and attract numerous attention from synthetic organic chemists due to their fascinating biological properties and associated synthetic challenges. We present herein that Pd-phosphoramidite catalysts promote the enantioselective dearomative allylic annulation reaction between allyl desoxyhumulones and allylic dicarbonates, affording PPAPs analogues in good yields and enantioselectivities. The reaction likely proceeds through two-step dearomative allylation by Pd, and the C-allylation pathway is the dominant mechanistic model.
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