Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Automated summary

In this study, a Ni-catalyzed reductive transamidation was reported, allowing for the synthesis of various amides with good yields and a broad substrate scope. Furthermore, the same catalytic reaction conditions were applicable for N-sulfonyl benzotriazoles, enabling the synthesis of corresponding sulfonamides.