Journal
ORGANIC LETTERS
Volume 24, Issue 5, Pages 1258-1262Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00209
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Funding
- National Key R&D Program of China [2018YFA0702001]
- NSFC [21901235, 22071224]
- USTC [KY2060000121, WK2060190095, KY2060000143]
- USTC Research Funds of the Double First-Class Initiative [YD2060002010]
- Anhui Provincial Natural Science Foundation [1908085MB34]
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The nickel-catalyzed benzylic substitution reaction of secondary phosphine oxide was described, providing dialkylated P-stereogenic tertiary phosphine oxides with high to excellent enantioselectivities. The reaction was performed under mild conditions using commercially available benzyl chlorides and bench-stable secondary phosphine oxides, and exhibited broad functional group tolerance. This work represents a practical example for the preparation of P-stereogenic phosphine compounds.
A nickel-catalyzed benzylic substitution of secondary phosphine oxide was described, affording the dialkylated Pstereogenic tertiary phosphine oxides with high to excellent enantioselectivities. The reaction was performed under mild conditions with commercially available benzyl chlorides and bench stable secondary phosphine oxides, exhibiting broad functional group tolerance. It represented a practical example for the preparation of P-stereogenic phosphine compounds.
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