Silver-Catalyzed Trifluoromethoxylation of Aziridines

We disclose a silver-catalyzed trifluoromethoxylation of N-tosyl aziridines with trifluoromethyl arylsulfonate. The protocol is characterized by its mild conditions, simple operations, and good chemo- and regioselectivity. In addition, the trifluoromethoxylation of trisubstituted aziridines could construct C-OCF3 quaternary centers exclusively, which is quite rare. This method unlocks a new catalytic blueprint for accessing beta-trifluoromethoxylated amines, which could be important building blocks in synthetic chemistry.

Automated summary

A silver-catalyzed trifluoromethoxylation reaction has been disclosed, enabling the synthesis of β-trifluoromethoxylated amine compounds. This method offers mild conditions, simple operations, and high selectivity for the construction of quaternary centers.