Journal
ORGANIC LETTERS
Volume 23, Issue 22, Pages 8888-8893Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03387
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Funding
- DST INSPIRE Faculty Award [DST/INSPIRE/04/2015/002518]
- INSPIRE
- IISER K
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In this study, enantioselective C(sp(3))-H bond functionalizations of 2-alkyl azaarenes were achieved using a cooperative dual Lewis acid catalysis, showing good to excellent yields and selectivity across a range of complex molecular scaffolds while accepting a wide variety of functional groups.
Herein, we describe the enantioselective C(sp(3))-H bond functionalizations of 2-alkyl azaarenes using a cooperative dual Lewis acid catalysis. An achiral Lewis acid activates the unactivated azaarene partner without the need for a strong base. Orthogonally, a chiral-at-metal Lewis acid catalyst enables LUMO lowering and induces chirality. This method tolerates a range of complex molecular scaffolds and exhibits good to excellent yields and selectivity while accepting a wide variety of functional groups.
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