Journal
ORGANIC LETTERS
Volume 24, Issue 6, Pages 1329-1334Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04366
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Funding
- National Natural Science Foundation of China [21772094, 21977049]
- Research Foundation of Guizhou University [202016]
- Natural Science Foundation of Jiangsu Province [BK20191306]
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The first palladium-catalyzed asymmetric addition of arylboronic acids to coumarins has been successfully developed, providing a straightforward and asymmetric approach for the synthesis of pharmaceutically important 4-aryl-3,4-dihydrocoumarins. This methodology employs easily accessible and stable ligands, has a broad substrate scope, can be conducted under mild reaction conditions, and allows for the accommodation of electron-withdrawing arylboronic acids.
The first palladium-catalyzed asymmetric addition of arylboronic acids to coumarins was successfully established, providing a straightforward asymmetric approach to achieving pharmaceutically important 4-aryl-3,4-dihydrocoumarins. This methodology features easily accessible and bench-stable ligands, a wide substrate scope, mild conditions, and accommodation of electron-withdrawing arylboronic acids.
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