Journal
ORGANIC LETTERS
Volume 24, Issue 3, Pages 966-970Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04332
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Funding
- National Natural Science Foundation of China [21871087, 21702088]
- Open Research Fund of Key Laboratory of Polar Materials and Devices, Ministry of Education
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A novel Bronsted-acid-promoted selective C2-N1 ring-expansion reaction of indoles has been developed for the efficient preparation of fused quinolines. The process offers advantages such as high yields, good functional group tolerance, and simplicity.
A novel Bronsted-acid-promoted selective C2-N1 ring-expansion reaction of indoles has been developed that provides a rapid and efficient protocol for the preparation of fused quinolines. A variety of corresponding quinolines were obtained in high yields. Controlled experiments revealed that C2-spiroindolenines might be intermediates of this C2-N1 ring-expansion reaction. The notable advantages of this process include excellent yields, good functional group tolerance, and operational simplicity.
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