Journal
ORGANIC LETTERS
Volume 24, Issue 3, Pages 916-920Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04267
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Funding
- National Institute of Dental and Craniofacial Research Grant [R21DE029156]
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Here, we report the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method shows good yields in converting primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds, including derivatives of complex bioactive molecules.
Polyfluoroarene moieties are of interest in medicinal chemistry, agrochemicals, and material sciences. Herein, we present the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method converts primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds in good yields in the presence of amide, carbamate, ester, aromatic, and sulfonamide moieties, including derivatives of complex bioactive molecules. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after the halogen atom transfer.
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