Journal
ORGANIC LETTERS
Volume 24, Issue 2, Pages 786-790Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04336
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Funding
- Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2019R01005]
- Taizhou University
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A scalable cyanation method for the synthesis of (hetero)arylacetonitrile derivatives from gem-difluoroalkenes has been developed. This method offers mild reaction conditions, excellent yields, a wide range of applicable substrates, and tolerance to various functional groups. Notably, the use of aqueous ammonia as a nitrogen source eliminates the need for toxic cyanating reagents or metal catalysts, providing a green and alternative approach for the synthesis of arylacetonitriles.
A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitrile derivatives was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope, and broad functional group tolerance. Significantly, in this reaction, aqueous ammonia offers a N source for the CN reagent and entirely avoids the use of toxic cyanating reagents or metal catalysis. Hence, we provide a green and alternative method for the synthesis of arylacetonitriles.
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