Journal
ORGANIC LETTERS
Volume 24, Issue 7, Pages 1439-1443Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04306
Keywords
-
Categories
Funding
- JSPS KAKENHI [JP16H06351, JP19K05452, JP21H04703]
- JST SPRING [JPMJSP2106]
Ask authors/readers for more resources
The first total synthesis of saptomycin H is reported in this study, which allows the determination of the unidentified absolute stereochemistry of the oxiranyl side chain as 14R,16S. The key steps include the concise assembly of three units (anthrone, sugar, and side chain) and the AZADOL-mediated 6-endo-selective pyranone formation.
We report herein the first total synthesis of saptomycin H (2), by which the unidentified absolute stereochemistry of the oxiranyl side chain has been determined as 14R,16S. The keys include (1) concise assembly of three units, anthrone, sugar and side chain, and (2) AZADOL-mediated 6-endo-selective pyranone (A-ring) formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
