Journal
ORGANIC LETTERS
Volume 23, Issue 24, Pages 9419-9424Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03541
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Funding
- Ministry of Science and Technology [MOST 110-213-M-037-017]
- Centre for Research Resources and Develop-ment of Kaohsiung Medical University
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The study presents a new set of reactions for unlocking amides using allyl bromide, providing a common platform for accessing various nitrogen-containing functional groups. The method shows potential industrial applicability through gram-scale syntheses in both batch and continuous flow systems.
We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.
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