Journal
ORGANIC LETTERS
Volume 24, Issue 1, Pages 304-308Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03967
Keywords
-
Categories
Funding
- NSFC [21925109, 21772170]
- Open Research Fund of School Chemistry and Chemical Engineering, Henan Normal University
- Center of Chemistry for Frontier Technologies of Zhejiang University
Ask authors/readers for more resources
A Pd-catalyzed atroposelective C-H allylation with 1,1-disubstituted alkenes was carried out using the chiral ligand L-pGlu-OH, resulting in the synthesis of enantioenriched N-aryl peptoid atropisomers. High yields and excellent enantioselectivities were achieved, with up to 90% yield and 97% ee.
A Pd-catalyzed atroposelective C-H allylation with 1,1-disubstituted alkenes was developed for the synthesis of enantioenriched N-aryl peptoid atropisomers via beta-H elimination using commercially available and inexpensive L-pGlu-OH as a chiral ligand. Exclusive allylic selectivity was achieved. Additionally, a series of enantioenriched N-aryl peptoid atropisomers were obtained in synthetically useful yields with excellent enantioselectivities (up to 90% yield and 97% ee).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available