Journal
ORGANIC LETTERS
Volume 23, Issue 20, Pages 8098-8103Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03232
Keywords
-
Categories
Funding
- Shandong Lunan Coal Chemical Research Institute of Engineering and Technology, Zaozhuang University
- Zaozhuang Science and Technology Development Program [2018GH19]
- NSF [CHE-1650766]
- Rutgers University
- Nanjing University of Information Science and Technology
Ask authors/readers for more resources
The Pd-catalyzed double-decarbonylative synthesis of aryl thioethers involves an aryl exchange reaction between amides and thioesters, with amides serving as aryl donors and thioesters as sulfide donors. The use of Pd/Xantphos without any additives promotes aryl exchange by C(O)-N/C(O)-S cleavages, allowing for a wide variety of amides and sulfides to be used in the reaction.
We report the palladium-catalyzed double-decarbonylative synthesis of aryl thioethers by an aryl exchange reaction between amides and thioesters. In this method, amides serve as aryl donors and thioesters are sulfide donors, enabling the synthesis of valuable aryl sulfides. The use of Pd/Xantphos without any additives has been identified as the catalytic system promoting the aryl exchange by C(O)-N/C(O)-S cleavages. The method is amenable to a wide variety of amides and sulfides.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
