Journal
ORGANIC LETTERS
Volume 23, Issue 23, Pages 9025-9029Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02792
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Funding
- JSPS [JP19K16328, JP16H07340, JP19K05466, JP24249001, JP23105006]
- Ritsumeikan Global Innovation Research Organization (R-GIRO) project
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The synthesis of 2-oxygenated dihydrobenzofurans via [3 + 2] coupling of quinone monoacetals with vinyl ethers has been achieved using tetrabutylammonium triflate catalysis. This new method involves activating the acetal moiety in quinone monoacetals under acid-free conditions to obtain highly oxygenated dihydrobenzofurans, with triflate anion catalyst stabilizing the cationic intermediate.
The synthesis of 2-oxygenated dihydrobenzofurans involving the [3 + 2] coupling of quinone monoacetals with vinyl ethers has been realized by tetrabutylammonium triflate catalysis. The reaction involves a new activation method of the acetal moiety in quinone monoacetals under acid-free conditions affording the highly oxygenated dihydrobenzofurans. This new activation mode was achieved by using the triflate anion catalyst for stabilization of the highly reactive cationic intermediate.
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