Journal
ORGANIC LETTERS
Volume 24, Issue 1, Pages 374-378Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04028
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [22193011, 21971120, 21933008]
- National Science & Technology Fundamental Resource Investigation Program of China [2018FY201200]
Ask authors/readers for more resources
N-N axially chiral skeletons play important roles in natural products, pharmaceuticals, and functional materials. A method for asymmetric synthesis of these compounds using phase-transfer catalysis was successfully developed, resulting in high yields and excellent stereoselectivities. The mechanism was further elucidated through density functional theory calculations.
N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone derivatives were prepared in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. Density functional theory calculations provide insight into the mechanism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available