Journal
ORGANIC LETTERS
Volume 23, Issue 22, Pages 8822-8827Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03329
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Funding
- National Natural Science Foundation of China [21901175]
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A photoredox-catalyzed radical cascade reaction has been developed for the synthesis of lactam-substituted gem-difluoroalkenes, providing a simple method with good functional group tolerance and high yields.
Herein, the synthesis of lactam-substituted gem-difluoroalkenes has been developed through a photoredox-catalyzed radical cascade reaction. This developed photoredox-catalyzed, Bronsted base-assisted intramolecular 5-exo-trig cyclization/intermolecular radical addition/beta-fluoride elimination reaction offers a simple method for producing lactam, carbamate, or ureasubstituted gem-difluoroalkenes with good functional group tolerance and high yields.
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