Photoredox-Catalyzed Difunctionalization of Unactivated Olefins for Synthesizing Lactam-Substituted gem-Difluoroalkenes

Herein, the synthesis of lactam-substituted gem-difluoroalkenes has been developed through a photoredox-catalyzed radical cascade reaction. This developed photoredox-catalyzed, Bronsted base-assisted intramolecular 5-exo-trig cyclization/intermolecular radical addition/beta-fluoride elimination reaction offers a simple method for producing lactam, carbamate, or ureasubstituted gem-difluoroalkenes with good functional group tolerance and high yields.

Automated summary

A photoredox-catalyzed radical cascade reaction has been developed for the synthesis of lactam-substituted gem-difluoroalkenes, providing a simple method with good functional group tolerance and high yields.