Journal
ORGANIC LETTERS
Volume 24, Issue 4, Pages 1055-1059Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04280
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Funding
- National Natural Science Foundation of China [21803059, U1904212, U2004191]
- Natural Science Foundation of Henan Province [202300410477]
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A copper-catalyzed delta-regioselective C(sp(3))-H heteroarylation of N-fluorosulfonamides has been developed, providing a practical strategy for the functionalization of heteroarenes and amides via forging a C(sp(3))-C(sp(2)) bond. A broad range of heteroarenes were well tolerated and reacted with various N-fluorosulfonamides to give the corresponding heteroarylated amides in good yields. Notably, all types of delta-C(sp(3))-H bonds in the N-fluorosulfonamides could be regioselectively activated through the 1,5-HAT process.
A copper-catalyzed delta-regioselective C(sp(3))-H heteroarylation of N-fluorosulfonamides has been developed. A broad range of heteroarenes were well tolerated and reacted with various N-fluorosulfonamides to give the corresponding heteroarylated amides in good yields. Notably, all types (1 degrees, 2 degrees, and 3 degrees) of delta-C(sp(3))-H bonds in the N-fluorosulfonamides could be regioselectively activated through the 1,5-HAT process. This protocol provides a practical strategy for the functionalization of heteroarenes and amides via forging a C(sp(3))-C(sp(2)) bond.
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