Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Automated summary

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed, which does not require metals, light, or catalysts, making the protocol operationally simple and more sustainable.