Phosphination of Phenol Derivatives and Applications to Divergent Synthesis of Phosphine Ligands

We describe a general and efficient protocol for the synthesis of organophosphine compounds from phenols and bond formation process. This approach exhibits broad substrate scope and excellent functional group tolerance. The synthetic utilities of this protocol were demonstrated by the synthesis of chiral ligands via the various transformations of cyano groups and their applications in asymmetric catalysis.

Automated summary

A general and efficient protocol for synthesizing organophosphine compounds from phenols and bond formation process is described in this study. The approach has broad substrate scope and excellent functional group tolerance, and its synthetic utilities were demonstrated by the synthesis of chiral ligands through various transformations of cyano groups for applications in asymmetric catalysis.