Journal
ORGANIC LETTERS
Volume 23, Issue 20, Pages 8114-8118Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03258
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Funding
- Novartis
- PHT International
- NSF [CHE 18-56406]
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Commercially available Pd/C catalyst with only 0.4 mol % Pd loading can be used for nitro group reductions. The reaction can be carried out using silane or a hydrogen balloon, resulting in high yields of desired amines. Both the catalyst and surfactant can be recycled without loss of reactivity.
Commercially available Pd/C can be used as a catalyst for nitro group reductions with only 0.4 mol % Pd loading. The reaction can be performed using either silane as a transfer hydrogenating agent or simply a hydrogen balloon (similar to 1 atm pressure). With this technology, a series of nitro compounds was reduced to the desired amines in high chemical yields. Both the catalyst and surfactant were recycled several times without loss of reactivity.
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