Journal
ORGANIC LETTERS
Volume 23, Issue 20, Pages 7814-7818Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02834
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21602231]
- Natural Science Foundation of Jiangsu Province [BK20191197]
Ask authors/readers for more resources
A family of axially chiral azepine-containing seven-membered cyclic P,N-ligands, named Indole-azepinap, was prepared using L-alanine as an original chirality source. The direct chromatographic separation of two diastereomeric phosphine oxides on silica gel allowed easy accessibility of these ligands for further structural and electronic modifications. These Indole-azepinaps showed promising results in a Pd-catalyzed asymmetric allylic alkylation with high yields and moderate enantioselectivities.
A family of axially chiral azepine-containing seven-membered cyclic P,N-ligands (named Indole-azepinap) have been prepared by using L-alanine as an original chirality source. The direct chromatographic separation of two diastereomeric phosphine oxides on silica gel enabled these ligands to be easy available, allowing further structural and electronic modifications. Preliminary application of these Indole-azepinaps has been demonstrated in a Pd-catalyzed asymmetric allylic alkylation with high yields and moderate enantioselectivities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available