Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 2, Pages 345-351Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob01717a
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Funding
- DST-INSPIRE, New Delhi, India [DST/INSPIRE Fellowship/2017/IF70456]
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The regioselective syntheses of N-1 and N-2 substituted triazoles through 1,6-addition reaction to p-quinone methide demonstrate superior results in terms of selectivity, mild reaction conditions, and broad substrate scope with good functional-group compatibility. This strategy holds great synthetic value and is beneficial for researchers in various fields.
The regioselective syntheses of N-1 and N-2 substituted triazoles through a 1,6-addition reaction of 1,2,3-NH triazoles to p-quinone methide were achieved under mild reaction conditions. The present reactions showed superior results in terms of selectivity, mild reaction conditions, short reaction time and broad substrate scope with good functional-group compatibility. Considering the high synthetic value of N-1- and N-2-substituted compounds and p-QM related research, the present strategy will greatly benefit researchers in various fields.
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