Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 5, Pages 1112-1116Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob02273c
Keywords
-
Categories
Funding
- National Natural Science Foundation of China (NSFC) [21676252, 21506191]
Ask authors/readers for more resources
The direct synthesis of isocoumarin skeletons was achieved through a Rh(iii)-catalyzed [3 + 3] annulation of sulfoxonium ylides with iodonium carbenes. The synthetic protocol showed broad functional group tolerance and mild reaction conditions, and can be viewed as the result of C-H activation, carbene insertion, and nucleophilic addition processes. The effectiveness of the synthesis protocol was supported by further product conversions and gram-scale reactions.
The direct synthesis of isocoumarin skeletons has been realized through the Rh(iii)-catalyzed [3 + 3] annulation of sulfoxonium ylides with iodonium carbenes. The synthetic protocol was constructed efficiently with broad functional group tolerance and mild reaction conditions. This reaction can be formally viewed as the result of C-H activation, carbene insertion and nucleophilic addition processes. Furthermore, the further conversions of the product and gram-scale reactions were also demonstrate to support the effectiveness of the synthesis protocol.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available