Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 4, Pages 773-777Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob02087k
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Funding
- Science & Engineering Research Board (SERB), Department of Science and Technology (DST), India [EMR/2017/002601]
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A novel synthesis strategy was proposed for the formation of N-bridged pyridine fused quinolone derivatives via a tandem reaction, which not only constructs multiple bonds in a single operation but also proceeds under transition metal-free conditions, demonstrating broad substrate scope and gram scale synthesis.
Herein, we present a tandem aza-Michael addition-vinylogous aldol condensation strategy for the synthesis of N-bridged pyridine fused quinolone derivatives from quinolones and ynones. The presented tandem transformation features the construction of C-N and C = C bonds in a single operation, under transition metal-free conditions. The wide substrate scope and gram scale synthesis of pyridine fused quinolone derivatives expand the synthetic value of the presented protocol.
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