Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 9, Pages 1969-1973Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00123c
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Funding
- Science and Technology Commission of Shanghai Municipality [18431907100]
- State Key Laboratory of Drug Research Program [SIMM2103ZZ-03, LG202103-02-03]
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A method of direct C-4 selective alkylation of pyridines under visible light irradiation at room temperature is reported. The method uses simple maleate-derived pyridinium salts as pyridine precursors and readily available carboxylic acid-derived N-(acyloxy)phthalimides as alkyl radical precursors, affording good to excellent yields without using stoichiometric oxidants and acids.
A method of direct C-4 selective alkylation of pyridines under visible light irradiation at room temperature has been reported, using simple maleate-derived pyridinium salts as pyridine precursors and the readily available carboxylic acid-derived N-(acyloxy)phthalimides as alkyl radical precursors, affording good to excellent yields without using stoichiometric oxidants and acids. A broad range of primary, secondary, and tertiary carboxylates can be used as alkylation reagents. Oxidant and acid-sensitive functional groups can be tolerated well.
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