Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 12, Pages 2356-2369Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00126h
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Funding
- National Natural Science Foundation of China [21602085]
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Enaminones and analogous stable enamines are widely used as platform building blocks in organic synthesis for constructing heterocyclic compounds, especially N-heterocycles. Recently, synthetic protocols based on the C-N bond cleavage of enamines have achieved notable success in the development of transition metal-free heterocyclic product synthesis.
Enaminones and analogous stable enamines are well known as platform building blocks in organic synthesis for the construction of heterocyclic compounds, especially N-heterocycles. To date, enaminones have been successfully employed in the synthesis of various 5- or 6- membered heterocycles. Recently, synthetic protocols accomplished by diversity-oriented annulation reactions based on the C-N bond cleavage of enamines have gained notable success. In this review, the development of the transition metal-free heterocyclic product synthesis based on the annulation reactions of enaminones or analogous enamines featuring a C-N bond cleavage is reviewed.
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