Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as C=C-N donors

Nitrogen-containing heterocycles are ubiquitous fragments of numerous natural products, pharmaceuticals, designed bioactive drug candidates and agrochemicals. During the past few decades, these compounds have received considerable attention from the synthetic chemistry community, and great efforts have been focused on the development of concise and efficient methods for the synthesis of these heterocyclic skeletons. In this review, we summarize a diverse range of synthetic methods employing beta-aminovinyl esters(ketones) as key C=C N-synthons to furnish useful bioactive heterocyclic frameworks, such as quinolines, pyridines, pyrazines, pyrroles, indoles, oxazoles, imidazoles, thiazoles, isothiazoles, pyrazoles, triazoles, and azepines, thus offering new opportunities and expanding the toolbox of synthetic chemistry reactions.

Automated summary

This review summarized a series of synthetic methods using beta-aminovinyl esters (ketones) to synthesize bioactive heterocyclic frameworks, providing new opportunities and expanding the toolbox of synthetic chemistry reactions.