Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 8, Pages 1690-1698Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob02496e
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Funding
- ANII (Agencia Nacional de Investigacion e Innovacion, Uruguay)
- PEDECIBA (Programa de Desarrollo de las Ciencias Basicas)
- CSIC (Comision Sectorial de Investigacion Cientifica)
- ANII
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A set of linear and cyclic oligomers were synthesized from a suitable azido-alkyne monomer through click oligomerization. The optimization of the click reaction was achieved using dimerization as a model reaction. The product distribution of the oligomerization could be controlled by the monomer concentration and the use of additives, resulting in mainly cyclic oligomers consisting of tetramers, pentamers, and hexamers.
A set of linear and cyclic oligomers were synthesized starting from a suitable azido-alkyne monomer through click oligomerization. The synthesis of these monomers starting from bromobenzene features an enzymatic dihydroxylation and the regio- and stereoselective installation of the azide and alkyne functionalities. Optimization of the click reaction was accomplished using dimerization as the model reaction. The product distribution of the oligomerization could be modulated by the monomer concentration and the use of additives, generating mainly cyclic oligomers consisting of tetramers, pentamers and hexamers.
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