Journal
ORAL DISEASES
Volume 29, Issue 1, Pages 21-28Publisher
WILEY
DOI: 10.1111/odi.14054
Keywords
bacteria; immunopathology; inflammatory diseases; microbiology; mouth; neuroinflammation; pathogenesis; periodontium
Categories
Ask authors/readers for more resources
Periodontitis is a chronic non-communicable disease caused by a dysbiotic microbiota. Pathogens can spread to the brain, induce an immune response, and lead to the development of Alzheimer's disease (AD). Studies have found oral bacteria in the brains of animals and AD patients, suggesting a potential oral-brain axis in the etiology of AD.
Periodontitis is a chronic non-communicable disease caused by a dysbiotic microbiota. Pathogens can spread to the bloodstream, colonize other tissues or organs, and favor the onset of other pathologies, such as Alzheimer's disease (AD). Pathogens could permanently or transiently colonize the brain and induce an immune response. Thus, we analyzed the evidence combining oral bacteria's detection in the brain, both in animals and humans affected with AD. This systematic review was carried out following the PRISMA guideline. Studies that detected oral bacteria at the brain level were selected. The search was carried out in the Medline, Latindex, SciELO, and Cochrane Library databases. SYRCLE tool and Newcastle-Ottawa Scale were used for the risk of bias assessment. 23 studies were selected according to the eligibility criteria. Infection with oral pathogens in animals was related to developing neuropathological characteristics of AD and bacteria detection in the brain. In patients with AD, oral bacteria were detected in brain tissues, and increased levels of pro-inflammatory cytokines were also detected. There is evidence of a microbiological susceptibility to develop AD when the most dysbiosis-associated oral bacteria are present. The presence of bacteria in the brain is related to AD's pathological characteristics, suggesting an etiological oral-brain axis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available