4.5 Review

Role of MRI-based radiomics in locally advanced rectal cancer

Journal

ONCOLOGY REPORTS
Volume 47, Issue 2, Pages -

Publisher

SPANDIDOS PUBL LTD
DOI: 10.3892/or.2021.8245

Keywords

LARC; radiomics; NCRT; MRI; imaging biomarkers

Categories

Funding

  1. Sichuan Science and Technology Program [2021YFG0320, 2020YJ0446]

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This review summarizes the applications, limitations and prospects of MRI-based radiomics in the treatment of locally advanced rectal cancer (LARC). Radiomics uses high-dimensional quantitative features extracted from medical imaging data to predict treatment response and prognosis, and has the potential to become an imaging biomarker for treatment prediction. However, there are still limitations and challenges in its current application.
Colorectal cancer is the third most common type of cancer, with high morbidity and mortality rates. In particular, locally advanced rectal cancer (LARC) is difficult to treat and has a high recurrence rate. Neoadjuvant chemoradiotherapy (NCRT) is one of the standard treatment programs of LARC. If the response to treatment and prognosis in patients with LARC can be predicted, it will guide clinical decision-making. Radiomics is characterized by the extraction of high-dimensional quantitative features from medical imaging data, followed by data analysis and model construction, which can be used for tumor diagnosis, staging, prediction of treatment response and prognosis. In recent years, a number of studies have assessed the role of radiomics in NCRT for LARC. MRI-based radiomics provides valuable data and is expected to become an imaging biomarker for predicting treatment response and prognosis. The potential of radiomics to guide personalized medicine is widely recognized; however, current limitations and challenges prevent its application to clinical decision-making. The present review summarizes the applications, limitations and prospects of MRI-based radiomics in LARC.

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