4.7 Article

SGLT inhibitors on weight and body mass: A meta-analysis of 116 randomized-controlled trials

Journal

OBESITY
Volume 30, Issue 1, Pages 117-128

Publisher

WILEY
DOI: 10.1002/oby.23331

Keywords

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Funding

  1. National University of Singapore Yong Loo Lin School of Medicine's Junior Academic Faculty Scheme

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This meta-analysis confirms the weight reduction benefits of SGLT inhibitors and indicates that SGLT1/SGLT2 inhibitors are more effective in reducing weight. However, further studies are needed to clarify their role in weight management.
Objective Multiple trials have demonstrated the metabolic effects of sodium/glucose cotransporter 2 (SGLT2) inhibitors in patients regardless of diabetes status, and recent trials have been conducted on the combined sodium/glucose cotransporter 1 and sodium/glucose cotransporter 2 (SGLT1/SGLT2) inhibitors. Therefore, a meta-analysis was conducted to investigate the weight reduction effects and dose-response relationship of SGLT inhibitors and to assess the relative efficacy of SGLT1/SGLT2 inhibitors. Methods Four electronic databases (PubMed, Embase, Cochrane, and Scopus) were searched on November 21, 2020, for articles published from January 1, 2000, up to November 21, 2020. Results In total, 116 randomized-controlled trials were included, with a combined cohort of 98,497 patients. Overall, patients had a mean weight reduction of -1.79 kg (95% CI: -1.93 to -1.66, p < 0.001) compared with placebo. This effect was observed across diabetes status, duration of follow-up, various comorbidities, and all SGLT drug types. Mean BMI changes were -0.71 kg/m(2) (95% CI: -0.94 to -0.47, p < 0.001) compared with placebo. Canagliflozin, empagliflozin, sotagliflozin, and licogliflozin showed a dose-response relationship for mean weight change. Compared with SGLT2 inhibitors, SGLT1/SGLT2 inhibitors had a significantly larger reduction in weight. Conclusions SGLT inhibitors demonstrated weight reduction benefits in this meta-analysis. Further studies are needed to clarify their role in weight management.

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