Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 40, Issue 12, Pages 1220-1236Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2021.1986222
Keywords
Chemo-enzymatic; nucleosides; Pseudomonas Cepacia lipase; REGIO-selectivity
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Biocatalysts have emerged as a sustainable alternative to conventional synthetic catalysts, exhibiting excellent selectivity and tolerance in the transformations of nucleosides and their analogs, particularly due to their multiple chiral centers.
Nucleosides play a pivotal role in biological systems and therefore have attracted a lot of interest as chemotherapeutic agents in drug discovery. Over the years biocatalysts have emerged as a sustainable alternative to conventional synthetic catalysts. As a nature's catalyst, they exhibit excellent selectivity, remarkable tolerance, and help in carrying out eco-friendly benign processes. The use of a biocatalyst as a regio- and enantioselective catalyst is particularly relevant in the transformations of nucleosides and their analogs because of the presence of multiple chiral centres. Herein, we discuss the recent advances in the Pseudomonas Cepacia Lipase mediated selective acylation and deacylation reactions of the secondary hydroxyl and amino groups of nucleosides and their analogs.
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