4.8 Article

ViroidDB: a database of viroids and viroid-like circular RNAs

Journal

NUCLEIC ACIDS RESEARCH
Volume 50, Issue D1, Pages D432-D438

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/nar/gkab974

Keywords

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Funding

  1. National Institutes of Health Oxford-Cambridge Scholars Program
  2. Edmond J. Safra Center for Bioinformatics at Tel-Aviv University
  3. European Research Council [ERC-AdG 787514]
  4. Intramural Research Program of the National Institutes of Health of the USA (National Library of Medicine)
  5. National Institutes of Health

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ViroidDB is a value-added database that collects known viroid and viroid-like circular RNA sequences, with about 10,000 unique sequences included. Each sequence's secondary structure, ribozyme content, and cluster membership are predicted through a custom pipeline optimized for circular RNAs. Users can explore the data through a purpose-built user interface, featuring visualizations, multiple sequence alignments, and bulk data download capabilities.
We introduce ViroidDB, a value-added database that attempts to collect all known viroid and viroid-like circular RNA sequences into a single resource. Spanning about 10 000 unique sequences, ViroidDB includes viroids, retroviroid-like elements, small circular satellite RNAs, ribozyviruses, and retrozymes. Each sequence's secondary structure, ribozyme content, and cluster membership are predicted via a custom pipeline optimized for handling circular RNAs. The data can be explored via a purpose-built user interface that features visualizations, multiple sequence alignments, and a portal for downloading bulk data. Users can browse the data by sequence type, taxon, or typo-tolerant search of metadata fields. The database is freely accessible at https://viroids.org.

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