Related references
Note: Only part of the references are listed.MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Junhong Guan et al.
CANCER CELL (2021)
ER-directed TREX1 limits cGAS activation at micronuclei
Lisa Mohr et al.
MOLECULAR CELL (2021)
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation
Mengjie Hu et al.
JOURNAL OF CLINICAL INVESTIGATION (2021)
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Tuo Li et al.
SCIENCE (2021)
Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
Li Zhong et al.
CELL DISCOVERY (2020)
ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways
Xu Feng et al.
EMBO JOURNAL (2020)
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
Ilgen Mender et al.
CANCER CELL (2020)
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase
Salim Abdisalaam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Attenuation of cGAS/STING activity during mitosis
Brittany L. Uhlorn et al.
LIFE SCIENCE ALLIANCE (2020)
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors
Lulu Wang et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Structural mechanism of cGAS inhibition by the nucleosome
Ganesh R. Pathare et al.
NATURE (2020)
BAF restricts cGAS on nuclear DNA to prevent innate immune activation
Baptiste Guey et al.
SCIENCE (2020)
cGAS suppresses genomic instability as a decelerator of replication forks
Hao Chen et al.
SCIENCE ADVANCES (2020)
Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy
Qiang Zhang et al.
CANCER RESEARCH (2019)
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS
Matthieu Gratia et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
Christian Zierhut et al.
CELL (2019)
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
Hui Jiang et al.
EMBO JOURNAL (2019)
Tight nuclear tethering of cGAS is essential for preventing autoreactivity
Hannah E. Volkman et al.
ELIFE (2019)
Active DNA end processing in micronuclei of ovarian cancer cells
Zizhi Tang et al.
BMC CANCER (2018)
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
Mingjian Du et al.
SCIENCE (2018)
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
Minxian Qian et al.
ELIFE (2018)
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
Haipeng Liu et al.
NATURE (2018)
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
Kareen Bartsch et al.
HUMAN MOLECULAR GENETICS (2017)
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination
Ronja Biehs et al.
MOLECULAR CELL (2017)
cGAS surveillance of micronuclei links genome instability to innate immunity
Karen J. Mackenzie et al.
NATURE (2017)
Mitotic progression following DNA damage enables pattern recognition within micronuclei
Shane M. Harding et al.
NATURE (2017)
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhixun Dou et al.
NATURE (2017)
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Selene Gluck et al.
NATURE CELL BIOLOGY (2017)
RAD51 interconnects between DNA replication, DNA repair and immunity
Souparno Bhattacharya et al.
NUCLEIC ACIDS RESEARCH (2017)
cGAS is essential for cellular senescence
Hui Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Evandro Fei Fang et al.
CELL METABOLISM (2016)
Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
David Millrine et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
Christine Wolf et al.
NATURE COMMUNICATIONS (2016)
Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases
Cosimo Pinto et al.
ELIFE (2016)
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
Anetta Hartlova et al.
IMMUNITY (2015)
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response
Alexandre Marechal et al.
CELL RESEARCH (2015)
DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells
Andreas Sturzenegger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1
Olivia Barton et al.
JOURNAL OF CELL BIOLOGY (2014)
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Atsushi Shibata et al.
MOLECULAR CELL (2014)
Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection
Nodar Makharashvili et al.
MOLECULAR CELL (2014)
Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress
Fengtao Su et al.
CELL REPORTS (2014)
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
Xin Li et al.
IMMUNITY (2013)
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Yosef Shiloh et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
Takeshi Kondo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
Jiaxi Wu et al.
SCIENCE (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Lijun Sun et al.
SCIENCE (2013)
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Xiao-Dong Li et al.
SCIENCE (2013)
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
Philip J. Kranzusch et al.
CELL REPORTS (2013)
The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR-Mediated Double-Strand Break Repair
Hailong Wang et al.
PLOS GENETICS (2013)
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
Amitabh V. Nimonkar et al.
GENES & DEVELOPMENT (2011)
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair
Shaun E. Peterson et al.
JOURNAL OF CELL BIOLOGY (2011)
Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks (vol 41, pg 529, 2011)
Lilach Moyal et al.
MOLECULAR CELL (2011)
Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination
Kyosuke Nakamura et al.
MOLECULAR CELL (2011)
Unrepaired clustered DNA lesions induce chromosome breakage in human cells
Aroumougame Asaithamby et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
Wassim Eid et al.
EMBO REPORTS (2010)
Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair
R. Scott Williams et al.
CELL (2009)
A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage
Janette Lloyd et al.
CELL (2009)
Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair
Pablo Huertas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
DNA Double-Strand Break Formation upon UV-Induced Replication Stress Activates ATM and DNA-PKcs Kinases
Hrohiko Yajima et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
J. Ross Chapman et al.
EMBO REPORTS (2008)
DNA helicases Sgs1 and BLM promote DNA double-strand break resection
Serge Gravel et al.
GENES & DEVELOPMENT (2008)
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin
Christoph Spycher et al.
JOURNAL OF CELL BIOLOGY (2008)
RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage
Rachel William Anantha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
Liming Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Human CtIP promotes DNA end resection
Alessandro A. Sartori et al.
NATURE (2007)
Phosphorylation of histone H2AX in radiation-induced micronuclei
Natalia G. Medvedeva et al.
RADIATION RESEARCH (2007)
Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions
Lance M. Hellman et al.
NATURE PROTOCOLS (2007)
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
J Falck et al.
NATURE (2005)
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage
ZK Lou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
CJ Bakkenist et al.
NATURE (2003)
Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability
H Tauchi et al.
ONCOGENE (2002)
NBS1 localizes to γ-H2AX foci through interaction with the FHA/BRCT domain
J Kobayashi et al.
CURRENT BIOLOGY (2002)
The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50•hMRE11•NBS1 complex DNA repair activity
H Tauchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
XH Wu et al.
NATURE (2000)
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
DS Lim et al.
NATURE (2000)