Rhea, the reaction knowledgebase in 2022

Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.

Automated summary

Rhea is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI, with recent developments including increased reaction coverage, adoption as the reference vocabulary for enzyme annotation in UniProtKB, and the development of a new Rhea website. These developments aim to enhance the utility of Rhea as a reference resource for studying enzymes and metabolic systems.