Journal
NUCLEIC ACIDS RESEARCH
Volume 50, Issue D1, Pages D54-D59Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkab1058
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Funding
- National Human Genome Research Institute of the National Institutes of Health [2 U41 HG007234]
- Spanish Ministry of Science, Innovation and Universities [PGC2018-097019-B-I00]
- Carlos III Institute of Health-Fondo de Investigacion Sanitaria [IPT17/0019-ISCIII-SGEFI/ERDF]
- `la Caixa' Banking Foundation [HR17-00247]
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APPRIS is a well-established database housing annotations for protein isoforms for a range of species, which selects principal isoforms based on protein structure and function features and cross-species conservation. The database has expanded to 10 model organisms and implemented TRIFID functional isoform scores as a significant change.
APPRIS (https://appris.bioinfo.cnio.es) is a well-established database housing annotations for protein isoforms for a range of species. APPRIS selects principal isoforms based on protein structure and function features and on cross-species conservation. Most coding genes produce a single main protein isoform and the principal isoforms chosen by the APPRIS database best represent this main cellular isoform. Human genetic data, experimental protein evidence and the distribution of clinical variants all support the relevance of APPRIS principal isoforms. APPRIS annotations and principal isoforms have now been expanded to 10 model organisms. In this paper we highlight the most recent updates to the database. APPRIS annotations have been generated for two new species, cow and chicken, the protein structural information has been augmented with reliable models from the EMBL-EBI AlphaFold database, and we have substantially expanded the confirmatory proteomics evidence available for the human genome. The most significant change in APPRIS has been the implementation of TRIFID functional isoform scores. TRIFID functional scores are assigned to all splice isoforms, and APPRIS uses the TRIFID functional scores and proteomics evidence to determine principal isoforms when core methods cannot.
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