Journal
NEW JOURNAL OF CHEMISTRY
Volume 46, Issue 2, Pages 877-882Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj04706j
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Funding
- National Natural Science Foundation of China [82073604, 81903369, 21906077]
- Natural Science Foundation of Hunan Province [2020JJ5474, 2019JJ50491]
- Scientific Research Fund of Hunan Provincial Education Department [20B508]
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N,S-CDs with strong orange fluorescence were synthesized through a hydrothermal method, showing excitation-independent photoluminescent behavior and excellent stability. A label-free and sensitive detection method for VB12 in drugs was established based on the inner filter effect between VB12 and N,S-CDs.
Nitrogen and sulfur co-doped carbon dots (N,S-CDs) with strong orange fluorescence were fabricated through a facile hydrothermal method using o-phenylenediamine and thiourea as precursors. The N,S-CDs exhibited excitation-independent photoluminescent behavior with excellent stability. The largest emission peak at 565 nm occurred at an excitation wavelength of 420 nm, and the quantum yield (QY) was 14.3%. It was found that the absorption spectra of vitamin B-12 (VB12) overlaps with the emission peak of the N,S-CDs to a large extent, and based on the inner filter effect (IFE) between VB12 and N,S-CDs, a label-free and sensitive detection method of VB12 in drugs was established. Under optimal conditions, the concentration of VB12 exhibited a satisfactory linear correlation with the fluorescence quenching degree Delta F/F-0 of the reaction system at 565 nm in the range of 0.25-20 mu M, and the detection limit was 77.5 nM. The N,S-CDs with orange fluorescence emission show huge potential for use in the field of biological analysis.
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