Journal
NEW JOURNAL OF CHEMISTRY
Volume 46, Issue 5, Pages 2239-2244Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj05749a
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Funding
- Ministry of Science and Technology of China, Henan [2016YFE0132600]
- Center for Outstanding Overseas Scientists [GZS2020001]
- Scientific and Technological Project of Henan Province [212102311068]
- Zhengzhou University
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An efficient multi-component reaction has been developed for the synthesis of 2,3-disubstituted tetrahydrofurans in a one-pot manner, providing a wide array of alpha-indole-beta-sulfonyl tetrahydrofurans in good yields with excellent selectivity, while avoiding the use of various additives and transition metals as catalysts.
An efficient multi-component reaction has been developed for the synthesis of 2,3-disubstituted tetrahydrofurans in a one pot manner, starting from readily available 2-arylindoles, arylsulfonyl azides, and tetrahydrofuran under simple and easily operated reaction conditions. This process provides a wide array of alpha-indole-beta-sulfonyl tetrahydrofurans in good yields with excellent selectivity, avoiding the use of various additives and transition metals as catalysts.
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