4.8 Article

Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar

Related references

Note: Only part of the references are listed.
Review Infectious Diseases

What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

Susanne H. Hodgson et al.

Summary: The development of a vaccine for the novel coronavirus is crucial to prevent the spread of the pandemic and reduce disease mortality. The efficacy endpoint is protection against severe disease and death, but evaluating this in phase 3 clinical trials poses challenges.

LANCET INFECTIOUS DISEASES (2021)

Article Medicine, General & Internal

COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Victoria Jane Hall et al.

Summary: The study aimed to determine the factors associated with vaccine coverage for two COVID-19 vaccines in the UK and to document the vaccine effectiveness of the BNT162b2 mRNA vaccine among healthcare workers. Results showed that the vaccine can prevent both symptomatic and asymptomatic infections in working-age adults, with a vaccine effectiveness of 70% after the first dose and 85% after the second dose.

LANCET (2021)

Letter Medicine, General & Internal

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

Laith J. Abu-Raddad et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic

Laith J. Abu-Raddad et al.

Summary: The study provided descriptive epidemiology of the SARS-CoV-2 epidemic in Qatar, showing age as the strongest predictor of severe, critical, or fatal infection. Most cases were asymptomatic. The rapid decline in cases was attributed to the growing immunity levels in the population.

SCIENTIFIC REPORTS (2021)

Article Immunology

SARS-CoV-2 Infection Is at Herd Immunity in the Majority Segment of the Population of Qatar

Mohamed H. Al-Thani et al.

Summary: Six in every 10 craft and manual workers in Qatar have been infected with COVID-19, suggesting the herd immunity threshold has been reached. The severity rate of infections was low, with the majority of infections being asymptomatic or mild.

OPEN FORUM INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar

Mohammad R. Hasan et al.

Summary: This study successfully characterized the transmission dynamics of the Alpha, Beta, and Delta variants of SARS-CoV-2 in Qatar between April and June 2021 using PCR genotyping and Sanger sequencing techniques.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Letter Medicine, General & Internal

Associations of Vaccination and of Prior Infection With Positive PCR Test Results for SARS-CoV-2 in Airline Passengers Arriving in Qatar

Roberto Bertollini et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Editorial Material Public, Environmental & Occupational Health

Pfizer-BioNTech mRNA BNT162b2 Covid-19 vaccine protection against variants of concern after one versus two doses

Laith J. Abu-Raddad et al.

JOURNAL OF TRAVEL MEDICINE (2021)

Article Medicine, General & Internal

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

Amy Flaxman et al.

Summary: The study shows that an extended interval before the second dose of the AstraZeneca vaccine leads to increased antibody titres, while a third dose significantly boosts antibody levels and enhances T-cell responses.

LANCET (2021)

Article Biochemistry & Molecular Biology

mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar

Hiam Chemaitelly et al.

Summary: A study showed that the mRNA-1273 vaccine is highly effective against the B.1.1.7 and B.1.351 variants of concern, with efficacy rates of 100% and 96.4% respectively. The vaccine's effectiveness increases rapidly in the weeks following the first dose, reaching maximum efficacy after the second dose, providing strong protection against severe COVID-19 outcomes.

NATURE MEDICINE (2021)

Editorial Material Medicine, General & Internal

Covid-19 Vaccine Effectiveness and the Test-Negative Design

Natalie E. Dean et al.

Summary: Observational studies are becoming crucial for assessing vaccine effectiveness, especially when large randomized controlled trials are not feasible. These studies can monitor vaccine efficacy waning and assess the effectiveness against new coronavirus variants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Letter Medicine, General & Internal

Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce

Jocelyn Keehner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Public, Environmental & Occupational Health

New COVID-19 Cases and Hospitalizations Among Adults, by Vaccination Status — New York, May 3–July 25, 2021

Eli S. Rosenberg et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 seroprevalence in the urban population of Qatar: An analysis of antibody testing on a sample of 112,941 individuals

Peter Coyle et al.

Summary: The study found that less than two in every 10 individuals in Qatar's urban population had detectable antibodies against SARS-CoV-2, indicating that herd immunity is still far off and there is a risk of subsequent infection waves. Higher antibody titers may serve as a biomarker of repeated exposures to the infection.

ISCIENCE (2021)

Article Multidisciplinary Sciences

A model and predictions for COVID-19 considering population behavior and vaccination

Thomas Usherwood et al.

Summary: The model explores the relationship between vaccination effectiveness and population behavior response, predicting COVID-19 infection trends and highlighting the impact of vaccination rate and changes in people's sense of safety on epidemic control.

SCIENTIFIC REPORTS (2021)

Article Medicine, General & Internal

Analysis of matched case-control studies

Neil Pearce

BMJ-BRITISH MEDICAL JOURNAL (2016)

Article Medicine, General & Internal

Analysis of matched case-control studies

Neil Pearce

BMJ-BRITISH MEDICAL JOURNAL (2016)

Article Immunology

The test-negative design for estimating influenza vaccine effectiveness

Michael L. Jackson et al.

VACCINE (2013)