4.8 Letter

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

Journal

NEW ENGLAND JOURNAL OF MEDICINE
Volume 385, Issue 21, Pages 2010-2012

Publisher

MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMc2115596

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The kinetics of immune response to Covid-19 vaccines were studied, showing varying peak levels and durations of response for different vaccines. However, the response levels correlating with protection have not been defined yet.
Kinetics of Immune Response to Covid-19 Vaccines B-cell and T-cell responses were measured to assess the stability and duration of vaccine-induced immunity. Responses to BNT162b2 and mRNA-1273 peaked early and declined over 6 to 8 months. The response to Ad26.CoV2.S reached a lower peak but continued without evidence of notable decline for 8 months. Response levels correlating with protection have not yet been defined.

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