Journal
NEUROSCIENCE RESEARCH
Volume 176, Issue -, Pages 79-84Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2021.10.003
Keywords
Olfactory dysfunction; First episode psychosis; Schizophrenia; Social cognition; Face processing
Categories
Funding
- National Institutes of Mental Health [MH-092443, MH-094268, MH-105660, MH-107730]
- Stanley
- RUSK/S-R
- NARSAD young investigator award from the Brain and Behavior Research Foundation
- Mitsubishi Tanabe Pharma Corporation
- [RUSK/S-R]
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Olfactory dysfunction is predictive in psychotic disorders and specifically associated with deficits in social cognition in early-stage psychosis.
Olfactory functional deficits have been reported in psychotic disorders. Olfactory dysfunction has a predictive value for prognosis and disease course. Thus, it is important to know which specific symptoms and cognitive changes are associated with olfactory dysfunction in early-stage psychosis. Deficits in social cognition are a difficult problem in psychosis. Here we conduct a detailed assessment of odor function and face processing and show that odor discrimination capacity is specifically associated with face processing function in patients with first episode psychosis. This finding indicates that the high-throughput olfactory assessment may aid a prediction of the difficult clinical dimension from early-stage psychosis.
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