Journal
NEUROSCIENCE LETTERS
Volume 766, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2021.136343
Keywords
Adult neurogenesis; Epigenetics; Epitranscriptomics; Learning and memory; Dentate gyrus; Neural stem cells; Hippocampus
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Funding
- National Institute of Mental Health [R01MH111773, R01MH122692]
- National Institute of Neurological Disorders and Stroke [R01NS1213000]
- Na-tional Institute on Aging [RF1AG071000, F31AG067718]
- Pharmacological Sciences T32 Training Program [T32GM135095]
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The adult dentate gyrus (DG) of the hippocampal formation generates new adult-born neurons from resident adult neural stem and progenitor cells (aNSPCs) through epigenetic regulation. The niche also utilizes epigenetic mechanisms in mature neurons and glial cells to direct the behavior of the aNSPCs.
The adult dentate gyrus (DG) of the hippocampal formation is a specialized region of the brain that creates new adult-born neurons from a pool of resident adult neural stem and progenitor cells (aNSPCs) throughout life. These aNSPCs undergo epigenetic and epitranscriptomic regulation, including 3D genome interactions, histone modifications, DNA modifications, noncoding RNA mechanisms, and RNA modifications, to precisely control the neurogenic process. Furthermore, the specialized neurogenic niche also uses epigenetic mechanisms in mature neurons and glial cells to communicate signals to direct the behavior of the aNSPCs. Here, we review recent advances of epigenetic regulation in aNSPCs and their surrounding niche cells within the adult DG.
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