Journal
NEUROSCIENCE LETTERS
Volume 765, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2021.136284
Keywords
Scutellarin; Depression; Neuroinflammation; Astrocyte
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Scutellarin alleviates depression-like behaviors induced by neuroinflammation partially through inhibiting the TLR4/NF-kappa B pathway in astrocytes.
Depression is a kind of common mental disorder associated with neuroinflammation, and astrocytes play a vital role in regulating and mediating neuroinflammation in central nervous system. Scutellarin has significant anti-inflammatory and neuroprotective effects. However, whether scutellarin exerts antidepressant effect remains unknown. In present study, it was found that scutellarin suppressed LPS-induced neuroinflammation in the hippocampus and alleviated depression-like behaviors in mice. In addition, scutellarin inhibited LPS-induced elevation of TNF alpha, IL-1 beta, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro. Furthermore, the activated TLR4/NF-kappa B pathway in LPS-treated astrocytes was suppressed by scutellarin. Collectively, these results suggest that scutellarin ameliorates depression-like behaviors induced by neuro -inflammation partially through inhibiting the TLR4/NF-kappa B pathway in astrocytes.
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