Inhibition in the auditory cortex

The auditory system provides us with extremely rich and precise information about the outside world. Once a sound reaches our ears, the acoustic information it carries travels from the cochlea all the way to the auditory cortex, where its complexity and nuances are integrated. In the auditory cortex, functional circuits are formed by subpopulations of intermingled excitatory and inhibitory cells. In this review, we discuss recent evidence of the specific contributions of inhibitory neurons in sound processing and integration. We first examine intrinsic properties of three main classes of inhibitory interneurons in the auditory cortex. Then, we describe how inhibition shapes the responsiveness of the auditory cortex to sound. Finally, we discuss how inhibitory interneurons contribute to the sensation and perception of sounds. Altogether, this review points out the crucial role of cortical inhibitory interneurons in integrating information about the context, history, or meaning of a sound. It also highlights open questions to be addressed for increasing our understanding of the staggering complexity leading to the subtlest auditory perception.

Automated summary

This review discusses the specific contributions of inhibitory neurons in the auditory cortex to sound processing and integration, examining the intrinsic properties of inhibitory interneurons and how inhibition shapes auditory cortex responsiveness to sound. It also explores the role of inhibitory interneurons in sound sensation and perception, highlighting the crucial role they play in integrating information and open questions for further understanding the complexity of auditory perception.