Journal
NEUROSCIENCE
Volume 480, Issue -, Pages 19-31Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2021.11.010
Keywords
RAD6B; PEDF; retina; degeneration; senescence; apoptosis
Categories
Funding
- National Natural Science Foundation of China [82071695, 82060535]
- Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital [CYXZ2021-07]
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RAD6B and PEDF play important roles in the health of the retina, and the absence of RAD6B accelerates retinal degeneration.
is an E2 ubiquitin-conjugating enzyme, playing an important role in DNA damage repair, gene expression, senescence, apoptosis and protein degradation. However, the specific mechanism between ubiquitin and retinal degeneration requires more investigation. Pigment epithelium-derived factor (PEDF) has a potent neurotrophic effect on the retina, protecting retinal neurons and photoreceptors from cell death caused by pathological damage. In this study, we found that loss of RAD6B leads to retinal degeneration in mice, especially in old age. Affymetrix microarray analysis showed that the PEDF signal was changed in RAD6B deficient groups. The expression of c-H2AX, b-Gal, P53, Caspase-3, P21 and P16 was increased significantly in retinas of RAD6B knockout (KO) mice. Our studies suggest that RAD6B and PEDF play an important role in the health of retina, whereas the absence of RAD6B accelerates the degeneration. (c) 2021 IBRO. Published by Elsevier Ltd. All rights reserved.
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