MRI of focal cortical dysplasia

Focal cortical dysplasia (FCD) are histopathologically categorized in ILAE type I to III. Mild malformations of cortical development (mMCD) including those with oligodendroglial hyperplasia (MOGHE) are to be integrated into this classification yet. Only FCD type II have distinctive MRI and molecular genetics alterations so far. Subtle FCD including FCD type II located in the depth of a sulcus are often overlooked requiring the use of dedicated sequences (MP2RAGE, FLAWS, EDGE) and/or voxel (VBM)- or surface-based (SBM) postprocessing. The added value of 7 Tesla MRI has to be proven yet.

Automated summary

FCD is classified into different types, with only FCD II showing distinctive MRI and molecular genetic alterations. Subtle FCD located in the depth of sulci are often overlooked and require the use of specialized sequences and postprocessing methods for diagnosis. The added value of 7 Tesla MRI has yet to be proven.